Pancreatitis Clinical Trials

Evaluation of Pirfenidone as a Novel Therapeutic Strategy Against Recurrent Acute Pancreatitis (PirfenidoneRAP)

This trial will look into if Pirfenidone can prevent additional recurrent attacks of acute pancreatitis and the progression to chronic pancreatitis.

This clinical trial tests Pirfenidone, a drug approved for treating a disease called pulmonary fibrosis. Over six months, the trial will look at Pirfenidone in recurrent acute pancreatitis patients to see its ability to reduce inflammation and prevent the recurrence of pancreatitis episodes, aiming to improve the quality of life for participants.

Johns Hopkins Pancreatitis Pain Program

Johns Hopkins Pancreatitis Pain Program is a research and patient care program that brings pain relief and hope to patients with chronic pain caused by pancreatitis. In this program, a team of experts provide new pain treatments to help improve patients’ quality of life.

The Johns Hopkins team includes experts in different areas such as pain, digestion, and mental health, working together to reduce patient pain caused by pancreatitis. Their approach uses medications and therapies that work on nerves in your head and gut to treat your whole body. This program is one of the only places in the world to study the connection between mental health, pain, and pancreatitis.

A Pilot Clinical Trial of Paricalcitol for Chronic Pancreatitis (ALLIANCE)

The proposed trial will examine the feasibility of testing the effect of the vitamin D analog, paricalcitol (also known as Zemplar), on health-related quality of life, imaging, and biomarkers in patients with chronic pancreatitis (CP).

This study is the initial stage of investigating whether Paricalcitol could benefit individuals with chronic pain, while also exploring specific markers to determine its effectiveness. It is our hope that paricalcitol treatment will improve symptoms and reduce the pain of chronic pancreatitis where there is currently no non-surgical option.

Safety and Efficacy of Mesenchymal Stem Cells Associated With Chronic Pancreatitis Pain (STEMCAP-1)

The investigators will test mesenchymal stem cells taken from the patient’s body as a treatment to reduce pain and inflammation due to chronic pancreatitis.

Mesenchymal stem cells have the proven potential to improve chronic pain in diseases. In this pilot study, participants will be given mesenchymal stem cells for chronic pancreatitis to measure changes in pain and quality of life as treatment is administered. This study may lead to mesenchymal stem cells as a standard of care if proven safe and effective.

Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis (STTEPP)

The researchers plan to study lacosamide, an FDA-approved anti-epilepsy medication, in combination with opioid therapy in patients suffering from chronic abdominal pain due to chronic pancreatitis (CP).

The researchers believe that combining lacosamide with opioids will enhance the effectiveness of opioids in managing pain in patients with chronic pancreatitis (CP). This study will look into what the best dosage of lacosamide and opioid is to best manage pain in CP patients.

SpHincterotomy for Acute Recurrent Pancreatitis (SHARP)

The purpose of this study is to investigate if an endoscopy procedure called Endoscopic Retrograde CholangioPancreatography (ERCP) with Minor Papilla Endoscopic Sphincterotomy (miES) can reduce the risk of recurrent acute pancreatitis.

The goal of this study is to see if a procedure called Endoscopic Retrograde CholangioPancreatography (ERCP) with sphincterotomy can lower the risk of pancreatitis or reduce the number of times patients with pancreas divisum get pancreatitis again. The researchers are looking for people diagnosed with pancreas divisum, who have had at least two episodes of pancreatitis, and might benefit from the ERCP with sphincterotomy procedure. If you fit this description, you may be eligible to take part in the study.

Long-Term Islet Function and Impact after Total Pancreatectomy with Islet Autotransplant (LIFT)

The University of Minnesota is looking for people aged 16 and older who had their pancreas completely removed, with or without an islet transplant, between 5 and 20 years ago. They aim to increase their understanding of diabetes after pancreas surgery.

This study aims to find out the long-term effectiveness of islet grafts (transplants) and their impact on diabetes complications after total pancreatectomy and autologous islet transplantation (TPIAT). Researchers want to improve the understanding of the body’s long-term blood sugar control. They will measure islet graft function by checking C-peptide levels during mixed meal tolerance tests. Individuals who had a total pancreatectomy with and without islet transplantation at any hospital are encouraged to participate; however, those without islet transplantation are especially needed. Participants will be required to visit the University of Minnesota for 2-3 days of testing. The clinical trial will cover travel costs and pay participants.

QST Study: Predicting Treatment Response in Chronic Pancreatitis Using Quantitative Sensory Testing

In this study, researchers will use Quantitative Sensory Testing (QST) to learn more about the patterns of pain in patients with Chronic Pancreatitis (CP), with the goal to predict therapy responses and improve treatment results.

QST is a new way of studying chronic pain in various diseases. Researchers will use it in this study to understand the pain patterns in patients with CP. QST uses a set of standardized tests to map out how the pain system works. QST could completely change how we treat CP patients and help predict treatment responses.

Pancreatic Quantitative Sensory Testing (P-QST) to Predict Treatment Response for Pain in Chronic Pancreatitis

Pancreatic Quantitative Sensory Testing (P-QST) is a new method of measuring pain sensitivity. In this clinical trial, they will test how well P-QST can predict pain improvement in patients with chronic pancreatitis (CP) after they receive endoscopic therapy or surgery.

Researchers will use the results from P-QST to create a tool to predict how a patient will respond to treatment. P-QST will be used to identify baseline pain before endoscopic therapy or decompressive surgery. The results will be used to test and create a model to estimate individual responses to treatment.

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