Drug Development Pipeline

Drug Development Pipeline — Mission: Cure

Identifying Targets and Therapies

In the past, few companies have invested in chronic and recurrent acute pancreatitis therapies, in part because researchers did not know what was causing the inflammation of the pancreas. Now, scientists are learning more about what causes the inflammation in many patients. When we know what biological processes are going wrong (called "targets"), researchers can work to identify therapies that will correct the problem.

Treatment Pipeline

Filter by pathway

Preclinical

Research & Development

7

Phase 1

Safety Testing

6

Phase 2

Efficacy Testing

2

Phase 3

Confirmatory Trials

0
Undisclosed
GondolaBio (a BridgeBio sister company)
Indication: Hereditary pancreatitisType: Biologic
Trigger
Undisclosed
Arwin Health
Target: SPINK1Type: Biologic
Trigger
Anti-Trypsin Antibody
Triveni Bio
Target: TrypsinType: Biologic
Trigger
PRSS1 Gene Therapy
Undisclosed
Target: PRSS1Type: Gene Therapy
Genetic/Hereditary
CBT-101
Cibus Therapeutics
Target: UndisclosedType: Small Molecule
Inflammation
RMS Stem Cell Therapy
Regenerative Medical Solutions
Target: Type 3c DiabetesType: Cell Therapy
Inflammation
Chemical Pancreatectomy
UPMC
Target: Pancreatic ParenchymaType: Procedure
Pain
● Recruiting
Mesenchymal Stem Cells
STEMCAP-1
Medical University of South Carolina
Target: Chronic pancreatitis painType: Allogeneic BM-MSC
Inflammation
● Recruiting
Mesenchymal Stem Cells
MSCPainRelief
VA Office of Research & Development
Target: Chronic pancreatitis painType: Autologous BM-MSC
Inflammation
● Recruiting
Pirfenidone
University of Alabama at Birmingham
Target: TGF-βType: Small Molecule
Scarring
Paricalcitol
Cedars-Sinai
Target: Vitamin D ReceptorType: Small Molecule
Scarring
Tocilizumab
TOPAC
Aalborg University Hospital
Target: IL-6 ReceptorType: Biologic
Inflammation
Indomethacin
Mayo Clinic
Target: COX-1/COX-2Type: Small Molecule
Inflammation
● Recruiting
Simvastatin
SMV in CP
Cedars-Sinai
Target: HMG-CoA ReductaseType: Small Molecule
Inflammation
Proglumide
CCKr Therapeutics
Target: CCK ReceptorType: Small Molecule
Scarring
No therapies currently in
Phase 3 trials.

Other

Personalized trials, observational studies & supportive care research

4
● Recruiting
Internet-Delivered Pain Self-Management for Acute Recurrent and Chronic Pancreatitis
IMPACT-2
An online program that teaches pain self-management skills to lessen the impact of pancreatitis pain and improve quality of life.
Pain
● Recruiting
Predicting Treatment Response Using Quantitative Sensory Testing
QST Study
Uses a painless sensory test to learn about pain patterns in chronic pancreatitis, with the goal of predicting who will respond to treatment.
Pain
Ivacaftor
N-of-1
Mission: Cure
Target: CFTRType: Small Molecule
Genetic/Hereditary
Pancreatic Quantitative Sensory Testing to Predict Pain Treatment Response
P-QST
Tests whether a painless pain-sensitivity measure can predict who will feel better after a procedure or surgery for chronic pancreatitis.
Pain
Pathway
Genetic/Hereditary
Trigger
Inflammation
Scarring
Pain
Status
Currently recruiting
Awaiting funding
Woman wearing a white lab coat.

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Identifying Targets and Therapies

In the past, few companies have invested in chronic and recurrent acute pancreatitis therapies, in part because researchers did not know what was causing the inflammation of the pancreas. Now, scientists are learning more about what causes the inflammation in many patients. When we know what biological processes are going wrong (called “targets”), researchers can work to identify therapies that will correct the problem.

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Before You Go

Get Updates in Your Inbox

Stay up-to-date on the latest Mission: Cure news and developments in pancreatitis care.







I am a...: